Fig. 1: Genetic characterization of MLAV.
值得注意的是，勐腊病毒可以感染蝙蝠，人类，猴子，仓鼠和狗的细胞系。像埃博拉病毒与Marburg病毒一样，勐腊病毒“表现出广泛的细胞趋向性，因此具有种间传播的高风险”，但目前尚未发现其感染人类的报道。
Abstract
Filoviruses, especially Ebola virus (EBOV) and Marburg virus (MARV), are notoriously pathogenic and capable of causing severe haemorrhagic fever diseases in humans with high lethality. The risk of future outbreaks is exacerbated by the discovery of other bat-borne filoviruses of wide genetic diversity globally. Here we report the characterization of a phylogenetically distinct bat filovirus, named Měnglà virus (MLAV). The coding-complete genome of MLAV shares 32–54% nucleotide sequence identity with known filoviruses. Phylogenetic analysis places this new virus between EBOV and MARV, suggesting the need for a new genus taxon. Importantly, despite the low amino acid sequence identity (22–39%) of the glycoprotein with other filoviruses, MLAV is capable of using the Niemann–Pick C1 (NPC1) as entry receptor. MLAV is also replication-competent with chimeric MLAV mini-genomes containing EBOV or MARV leader and trailer sequences, indicating that these viruses are evolutionally and functionally closely related. Finally, MLAV glycoprotein-typed pseudo-types transduced cell lines derived from humans, monkeys, dogs, hamsters and bats, implying a broad species cell tropism with a high risk of interspecies spillover transmission.
文献网址：https://www.nature.com/articles/s41564-018-0328-y
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